A Study Of The Heterocyclic Benzoxazole Derivatives Design, Synthesis, And Anti-Fungal Assessment

Abstract

A family of heterocyclic molecules having a variety of pharmacological actions, including antifungal qualities, are benzoxazole derivatives. The development of innovative antifungal drugs with enhanced effectiveness and decreased resistance is imperative due to the rise in fungal infections and the advent of drug-resistant strains. The design, synthesis, and antifungal evaluation of benzoxazole derivatives as possible antifungal drugs are examined in this work. A range of benzoxazole derivatives were created to investigate the structure-activity correlations influencing their antifungal efficacy via the use of molecular modeling tools. The suggested compounds were prepared using synthetic techniques, and their antifungal efficacy against therapeutically relevant fungal strains was later assessed. To evaluate the synthetic compounds' selectivity and safety profile, cytotoxicity experiments were carried out.