Association Between Serum Vitamin B12, Folic Acid And Nitric Oxide Levels In Patients Of Hypothyroid

Abstract

Introduction: Thyroid hormone is essential for proper development and proliferation of all cells in the human body, in addition to regulating the metabolism of blood cells. A deficiency in the water-soluble vitamin B12 results in a range of disorders. Its diagnostic and substantial role in patients with hypothyroidism has not been thoroughly investigated. A comparison was made between the concentrations of nitric oxide, vitamin B12, and folic acid in patients with hypothyroidism and thyroid hormones in the current study.

Material & Method: Enrolled in the study were 384 hypothyroid patients who were consulting the OPD of General Medicine and had been diagnosed with hypothyroidism. The control group consisted of fit individuals who were matched in age and sex. The concentrations of folic acid, vitamin B12, T3, T4, TSH, and NO in the serum were determined and compared to those of the control group.

Result: Serum levels of vitamin B12 were found to be substantially deficient in the current study, whereas levels of TSH, folic acid, and nitric oxide were found to be elevated. The levels of normal serum T3 and T4 did not differ significantly.

Conclusion: In comparison to healthy controls, the levels of TSH and nitric oxide in hypothyroid patients are significantly elevated, while serum folic acid and vitamin B12 levels are significantly decreased. According to the findings of the study, a deficiency in vitamin B12 may contribute to the onset of hypothyroidism.