"Exploring the Antidiabetic and Antioxidant Potential of Athiyadhi Kashayam: Investigating mechanisms of action in Siddha Medicine"

Abstract

Diabetes mellitus is a serious condition that affects the majority of the population and leads to mortality, and it may increase tremendously by 2025. The disease is characterized by elevated blood glucose levels resulting from insulin resistance and insufficiency. This leads to various metabolic disorders that affect various organs. The free radicals generated during diabetes conditions are known to elevate the condition much more severely. The antioxidant activity against free radicals and the inhibition of enzymes that are involved in raising blood glucose levels inhibition might prove effective in the treatment of type 2 diabetes. The Siddha formulation Athiyadi Kashayam (AK) was analyzed for its enzyme inhibition study and antioxidant activity in vitro. The results proved the enhanced antioxidant potential. The drug AK also inhibited the enzymes – amylase and glucosidase in a concentration-dependent manner. Thus AK proved to be effective in treating Type 2 Diabetes.