“Synthesis, Characterization And In Silico Studies Of Novel Substituted Azetidinone, Substituted Thiazolidinone Containing Naphthalene Moiety, With Their Biological Activity”

Abstract

A novel class of compounds (8-12) of azetidinone and (13-17) derivatives of drug, thiazolidinone were synthesis. Among of them, Synthesis of novel compound 9, N-(3-chloro-2-oxo-4-(p-tolyl)azetidin-1-yl)-2-(naphthalen-2-ylamino)acetamide) of series (8-12) ,  and compound 15 , N-(2-(4-chlorophenyl)-4-oxothiazolidin-3-yl)-2-(naphthalen-2-ylamino)acetamide of series (13-17) were showed valuable characteristic and efficacy as antibacterial activity. Chloro and nitro(compound no-10,11,51,16) substituted thiazolidinone derivatives were showed better biological activity as compare to standard drugs ciprofloxacin, for regarding this observation and same result find in molecular docking using Auto dock Vina against two proteins 4uro (DNA Gyrase b),3v7r (biotin protein ligase), heterocyclic compounds of these derivative are very useful in the field of medicinal chemistry. These derivatives of thiazolidinone as well as azetidinone nucleus possesses were show remarkable, better clinically efficacy with low toxicity. Purity of these derivatives were checked with the help of TLC. The structure of new synthesised compounds was identified and confirmed by elemental analysis, IR, NMR, and activity of new synthesised these drugs were screened for their antibacterial activity.