Synthesis And Antioxidant Activity Of Succinimide Derivative’’

Abstract

This reveals that the Succinic Anhydride and amine are pharmacologically more active units. The reaction of substituted Succinic anhydride with substituted amine and acetyl chloride to formation of succinimide derivatives Purity was checked by TLC and chemical structure of synthesized derivatives were elucidated by their IR, Proton NMR, MS analysis data. In this study Antioxidant activity was performed by DPPH (1, 1diphenyl-2-picrylhydrazyl) radical scavenging method. higher concentration possess better antioxidant potential when compare to reference standard ascorbic acid. They exhibited strong antioxidant DPPH radical scavenging activity with IC50 value of 9.3 and 24.8 µg/ml for ascorbic acid and alcoholic leaves extract respectively. The absorbance for reducing power was found to be 0.0390, 0.0989 for ascorbic acid and alcoholic leaves extract respectively. The strongest antioxidant activity of succinimide derivatives could be due to the presence of N, O and C.