Formulation Development & Evaluation of Mouth Dissolving Tablet of Torsemide

Abstract

The oral route of medication delivery is the most popular and generally recognized. Oral dose forms are frequently used since they are inexpensive and simple to administer on one's own. For example, mouth dissolving tablets dissolve in saliva and may be ingested without water. Torsemide is indicated for the treatment of oedema associated with congestive heart failure, renal, or hepatic diseases. This research is designed for fast release of drug for treatment of oedema. The tablets were prepared using Torsemide (Solid Dispersion), Crospovidone, Sodium Starch Glycolate, Mannitol, Magnesium Stearate, Talc, and Aspartame in eight different batches (T1-T8). The tablets were evaluated based on pre-compression characteristics of powder blend, weight variation test, thickness test, hardness, friability, drug content, wetting time, water absorption ratio, and disintegration time. According to the results, the T7 formulation outperformed the others in terms of disintegration time, water absorption ratio, and wetting time.