Phytopharmacological Evaluation of Colocasia Esculenta (L.) In Experimental Model of Anxiety Using LPS Induced Anxiety Model

Abstract

Colocasia esculenta Linn, also known as Taro, Arvi, Kachalu, Alupam, and Alukam, is a medicinal plant with flavonoids, β-sitosterol, and steroids as major constituents. Its leaves are rich in vitamin C, while its root is high in starch and essential nutrients. The extract of Colocasia esculenta has pharmacological activities such as central nervous effects, antioxidant, anti-inflammatory, analgesic, anti-lipid peroxidative activity, antidiabetic, antihepatotoxic, and antimicrobial effects. In our present study, the primary objective of this study is to conduct a comprehensive phytochemical analysis of C. esculenta, examining their secondary metabolites such as alkaloids, flavonoids, tannins, and phenolic compounds. The methodology involves qualitative screening through standard protocols to identify the presence of these compounds followed by quantitative analyses using Spectrophotometric techniques. Furthermore, isolation procedures will be employed to extract specific bioactive components for detailed characterization. Understanding the phytochemical profile of these plants can provide insights into their potential health benefits and applications in traditional medicine. Previous studies have indicated that C. esculenta exhibit anti-inflammatory, antioxidant, and antimicrobial activities; however, a detailed exploration of their chemical constituents remains limited. Hence, this research aims not only to fill this gap but also to contribute valuable information for future pharmacological studies on these economically important species. Ultimately, the findings from this investigation could support the development of natural products derived from C. esculenta for use in nutraceuticals or pharmaceuticals while promoting sustainable practices in utilizing indigenous plant resources. According to the previously mentioned study, evaluating all of the leaf extracts from Colocasia esculenta (L.) in conjunction with phytochemical analysis has yielded positive results, and the compounds found may be the source of the anti-anxiety properties. The assessment of the separated chemicals' anti-anxiety effectiveness from the plant's methanolic extracts further supports this conclusion. The current study aimed to provide scientific validation for anxiety-reducing practices. With further investigation, it will identify the exact mode of action of the extract and the isolated molecule that is responsible for its anti-anxiety effectiveness, paving the way for their ultimate application as therapeutic therapies after clinical trials.