Development and Characterization of Solid Self Nanoemulsifying Drug Delivery System Containing Polyherbal Tablet to The Treatment of Diabetes Mellitus

Abstract

The liquid nanoemulsifying drug delivery systems, also known as SNEDDS, have shown remarkable results in regard to the enhancement of the oral bioavailability of medicines that are poorly soluble. "an isotropic and thermodynamically stable system comprising of drug, oils, surfactants, and co-surfactant or co-solvents," is the definition of a self-emulsifying drug delivery system, also known as a SEDDS. SEDDS are administered in the form of an oil-in-water mixture, and when they come into touch with the contents of the stomach, they produce an emulsion that is either coarse, micro-, or nano-sized, depending on the composition of the stomach and the formulation process. The key process that helps SEDDS increase the dissolving rate is the natural formation of an emulsion inside the gastrointestinal tract as a result of moderate agitation generated by stomach movement. This is the mechanism that promotes SEDDS. The decrease in the size of the droplets leads to an increase in the interfacial area, which in turn facilitates the absorption of the medicine when it is administered. As a consequence of this, SEDDS improves the solubility of hydrophobic medicines in settings that include water. It has been shown that the use of SEDDS causes improvements in drug solubility, permeability, and lymphatic uptake, all of which contribute to an increase in the absorption of medications.