Development and Evaluation of Immediate Release Dosage Forms of Antimicrobials for Treatment of H. Pylori Infection

Abstract

A novel therapy comprising of an antibiotic a prostaglandin analogue in modified release dose form that would be an effective treatment for eradication of H. pylori infection. Helicobacter pylori (H. pylori) infection is highly associated with the occurrence of gastrointestinal diseases, including gastric inflammation, peptic ulcer, gastric cancer, and gastric mucosa-associated lymphoid-tissue lymphoma. Although alternative therapies, including phytomedicines and probiotics, have been used to improve eradication, current treatment still relies on a combination of antimicrobial agents, such as amoxicillin. The proposed therapy with immediate release of these drug could prove an effective treatment strategy for H. pylori infection in which reduces the inflammation and pain, drug inhibits the bacterial growth suppresses the acid secretion in stomach.